CD98 (SLC3A2/4F2 heavy chain) is a transmembrane protein that belongs to the solute carrier family. CD98 forms heterodimeric complexes with various amino acid transporters such as LAT1 and LAT2 and regulates uptake of amino acids. CD98 is an early expressed antigen on the surface of activated human lymphocytes, and is also expressed in most cell types with the exception of platelets. CD98 is highly expressed in the tubules of the kidney and the gastrointestinal tract. CD98 also expressed in tumors, including glioma, ovarian cancer, and astrocytomas. Expression of CD98 has been implicated in tumor progression and correlates with poor outcome in patients with pulmonary neuroendocrine tumors. CD98 is also involved in integrin trafficking through association with β1 and β4 integrins, and regulates keratinocyte adhesion and differentiation. Thus, CD98 is a widely expressed transmembrane protein involved in amino acid transport, integrin function, and differentiation.

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ECM Biosciences是一家著名的生物公司，开发新的生物技术的生命科学研究。公司工程与研究机构全球发展创新的工具，以提高研究和治疗相关的神经病理学，癌症，免疫功能障碍和心血管疾病。ECM Biosciences 的科学合作重点在分子组成部分，产生细胞运动的变化，细胞形状，促进细胞运动和细胞结构确定。细胞运动的重要作用在肿瘤细胞迁移，免疫细胞浸润，以及神经和血管修复。各种蛋白质在细胞外机质（ECM）周围细胞信号蛋白在细胞内的细胞骨架，以控制细胞运动 ECM Biosciences 生物利用创新肽和抗体为基础的办法，发展新的工具来检测和操作蛋白质功能的各个方面的细胞运动，如细胞黏附，细胞迁移和细胞信号。